Breath of the Wild
"A lizard found throughout Hyrule. It's a bit slow to react at times, but if given a chance to escape, it will dart off quickly. Cook it with monster parts for a speed-boosting elixir."
Hightail Lizards can commonly be obtained in many of the forests of the Great Plateau and the Necluda region. They can commonly found wherever there is tall grass. Link can use a metallic weapon, such as a Soldier's Broadsword and charge up a spin attack. This will cut a significant amount of the grass surrounding Link, and will often reveal a Hightail Lizard, along with Restless Crickets. Link can then very slowly walk over and grab the Hightail Lizard. If Link moves too fast, the noise will scare the lizard away.
Hightail Lizards can be cooked alongside monster parts to create Elixirs. The Hightail Lizard will give Link a Speed enhancement. When cooked with a monster part that has no specific enhancement, such as a Bokoblin Horn, Link will create a Hasty Elixir. This will temporarily boost Links movement speed. If Link cooks the Hightail Lizard along with food, it will result in Link making Dubious Food.
The Level 2 upgrades of the Climber's Bandanna, Climbing Gear, and Climbing Boots each require five Hightail Lizards, along with five Electric Keese Wings. The Level 2 upgrade of the Sand Boots requires five Hightail Lizards.
Age of Calamity
"A lizard found throughout Hyrule. It's a bit slow to react at times, but if given a chance to escape, it will dart off quickly. Its meat empowers leg muscles."
- Link: Spears Lv. 10 challenge (x10)
Hyrule Compendium entry of the Hightail Lizard.