The quest is unlocked after completing The Future of Hyrule scenario.
"One scientist was supposed to travel to Hebra to find an item for his Cryonis research, but he backed out at the last second due to family circumstances. Can you get it instead?"
"After a series of ups and downs, the researcher finally figured out how to upgrade Cryonis... yet he reacted without so much as a smile. It seemed he had something else on his mind."
- Reduced Time between Cryonis Uses