Many bosses in A Link to the Past have eyes as weak points. This boss is one of them. Vitreous has several small eyeballs protecting it, and it sends the small eyeballs to attack Link. The most efficient way to defeat these eyeballs is to attack them with Link's sword or shoot arrows at them. A good strategy for this phase is to go to the bottom-right corner of the room and face forward. Since Link swings his sword from right to left, keep button-mashing the sword button and all the small eyes will be defeated easily. Once all but four eyeballs are defeated, Vitreous will come out of its swamp and bounce around the room trying to attack Link. Run around in circles to avoid it while attacking it with Link's sword or shooting arrows at it. After several hits, Vitreous is vanquished, and the sixth Crystal is within Link's grasp.
- Vitreous' name comes from the vitreous humor, which is the clear gel that's found inside the eyeballs of vertebrates.
- In the deeper part of the liquid of Vitreous there are four eyes that never attack. They are only destroyed when Vitreous is defeated.