I can think of only five at the moment.
1) Dragon Age: Origins
Not only is this my favorite game of the seventh generation, but perhaps my favorite game of all time, a role contested only by the second game on the list. DA: O comes close to being the perfect RPG, with hundreds of factors playing into the story's progression. The story is fine and epic, with characters you love to love and villains you love to hate. The combat feels just right, combining the tactical nature we've come to expect from Bioware's fantastical offerings with the tense nature of real time. The lore is well defined and a joy to read about, and the writing is solid, bordering on brilliant. The five origins offered by the game give it a great sense of replayability, with each origin impacting how your story plays out in a significant way. And let's not forget the DLC that Bioware produced for the game, and boy did they produce a lot. There aren't many video games that can compel me to shell out more money for additional content, but Dragon Age is one of them (I personally didn't, because I bought the Ultimate Edition, but fugedaboudit). Each piece of DLC isn't necessary to play the original game, but each is a heartfelt piece of writing that expanded the universe into what is possibly the best RPG of all time.
Just don't play the second game.
Like, ever.
2) Mass Effect 1/2
It's probably cheating to include two games in one list, but I don't give a **** because this is my list. The first two Mass Effect games are two halves of the second contender for greatest RPG of all time, but the series is so much more than that. It's a space opera, epic in every sense of the word and perhaps the best presented of any RPG ever, combining the cinematic style of the 2009's Star Trek, with depth of player choice rivaled only by other games from the same developer, and some solid shoot 'em up gameplay. Though Metal Gear Solid features the most time-wasting of any game, with its overlong cutscenes and unexplained desire to wave exposition every which way, Mass Effect is the only game to come along and do it well. Until the third game came along and ruined everything. We don't talk about the third game.
3) Rayman Origins
Anyone who's played Rayman Origins can tell you why it makes this list. Colorful, smooth, and featuring a ridiculous difficulty curve that will **** you up the *** as you struggle to complete the final, secret level, Rayman Origins is platforming at is best. It doesn't condescend with big, colorful letters of Too Bad! like the more recent Mario titles. It doesn't feature power ups, or even a lives system. It's platforming simplicity, and that works just fine for Rayman Origins. The art style is easily the best of the generation, and could probably make the top ten list of best looking games in the past twenty years. Mario? **** Mario. Rayman's back.
4) Bioshock
I hadn't thought about Bioshock since finishing it a second time, but reading over the lists of the others who have mentioned it reminds me why it was such a brilliant stand-alone game in the first place. It was moody, atmospheric, and brilliantly written. For a game commonly classified as an RPG, it features one of the most challenging and evolving methods of killing people in any game to date, with the combination of plasmids, weaponry, and environmental hazards creating a tactical mess that is a joy to wade through, something few games these days have managed.
5) Jade Empire
I'm forcing this title onto the list because it was re-released for the PC in 2007, when the seventh generation of gaming was underway. Almost in spite of fantasy norms, where the world is based on a twisted variation of medieval Europe, Jade Empire moves the focus to China, where martial arts take precedence and the existence of spirits governing the world is considered an everyday part of life. While not the longest Bioware RPG, the substance far outweighs the shortcomings, with a well-written story of gods, power, and betrayal. Of all Bioware's games, Jade Empire perhaps features my favorite method of combat, involving a totally real-time system of rock, paper, and scissors, catering to almost anyone's taste, regardless of whether they prefer tactical gampelay, button-mashing, or killing people from a distance.