nah, I think the new Zelda game will be highlighted, since it obviously has to come out this year for the anniversary. I'm hoping it comes bundled with a special edition 3DS like they did with Mario Kart DS, though that probably won't happen. Anyway, my prediction is that it is a Four Swords game. Alternatively, it could just be that "Legend of Zelda Classic" or whatever from the rumored e-shop list.
Skyward Sword - playable demos of the first part(s) of the actual game rather than the made-up gameplay demo area. They'll talk about the orchestration. No definite release date, except something like "November" or "Holidays" or "2011"
Mario Kart 3D will have a trailer, and possibly a race between Reggie and Iwata (from what I understand, they used to have Super Smash Bros fights back in the day).
There will be quite a large (and overdue) spotlight on Pikmin 3. I'm inclined to believe the rumors that it will be for both the 3DS and the new console. They may use it at the conference to demonstrate the connectivity. It's also possible that all the Pikmin 3 for 3DS rumors (including the mention in the 3DS Iwata Asks) refer to the small demo that was shown last year and isn't supposed to become a full game. I'm hoping for this to be cleared up.