Being left-handed myself, I actually hold the wiimote in the left hand and find way more comfortable and play TP just fine. I'm not a pro, but everyone at the lakebed temple for the first time would say that! Being the first in motion control video game play system (Other than that fancy controller thing fromm the PS.), everyone is used to the standard arch/ovalular/rectangular controllers where you just plug the controller in and your done hooking it up. After some time those of us who usr the wiimote in their left hand can train ourselves to use it in the right hand without having to change our dominant hand.